Rilmenidine prevents epinephrine-induced arrhythmias in halothane-anesthetized dogs. J Cardiovasc Pharmacol 1995;26 Suppl 2:S40-3
Date
01/01/1995Pubmed ID
8642804DOI
10.1097/00005344-199512020-00007Scopus ID
2-s2.0-0029565278 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Stimulation of central alpha 2-adrenoceptors has been known to prevent epinephrine-induced arrhythmias in halothane-anesthetized dogs. Because recent studies suggested that several physiological processes that were traditionally attributed to activation of alpha 2-adrenoceptors, such as hypotensive action, are mediated through imidazoline receptors (IRs), it may be likely that IRs are involved in the antiarrhythmic action. We investigated the hypotensive effect of rilmenidine, a selective IR agonist (1, 3, and 10 micrograms/kg i.v.), and the antiarrhythmic effects of the drug on epinephrine-induced arrhythmias during halothane anesthesia in dogs. Although the hypotensive effect of rilmenidine was not remarkable in the dose range we tested, rilmenidine increased the arrhythmogenic threshold for epinephrine in a dose-dependent manner during halothane anesthesia, achieving statistical significance at 10 micrograms/kg, the highest dose we examined. These results suggest that rilmenidine prevents epinephrine-induced arrhythmias during halothane anesthesia and that this effect is more potent than its hypotensive action.
Author List
Mammoto T, Kamibayashi T, Hayashi Y, Takada K, Yamatodani A, Yoshiya IAuthor
Tadanori Mammoto MD, PhD Associate Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adrenergic alpha-AgonistsAnesthesia, Inhalation
Anesthetics, Inhalation
Animals
Antihypertensive Agents
Arrhythmias, Cardiac
Dogs
Dose-Response Relationship, Drug
Epinephrine
Female
Halothane
Imidazoline Receptors
Male
Oxazoles
Receptors, Drug