Selective beta 1 and beta 2 adrenoceptor blockade on epinephrine-induced arrhythmias in halothane anaesthetized dogs. Can J Anaesth 1992 Oct;39(8):873-6
Date
10/01/1992Pubmed ID
1283841DOI
10.1007/BF03008299Scopus ID
2-s2.0-0026498848 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
Beta 2 as well as beta 1 adrenoceptors have been recognized in the heart of vertebrates. They mediate a positive chronotropic action of catecholamines. We compared the effect of selective beta 1 and beta 2 adrenoceptor antagonists on the genesis of halothane-epinephrine arrhythmias in dogs. The arrhythmogenic dose (AD) of epinephrine was increased in the presence of l-metoprolol, a selective beta 1 antagonist (8.40 +/- 1.13 micrograms.kg-1 x min-1; mean +/- SEM), compared with control value (2.62 +/- 0.56) (P < 0.05). In contrast, ICI-118,551, a selective beta 2 antagonist, did not change the AD (2.36 +/- 0.43). Adding ICI-118,551 to l-metoprolol did not affect the AD of epinephrine in the presence of l-metoprolol alone (6.34 +/- 0.74 vs 8.40 +/- 1.13). These results suggest that selective beta 1 blockade is effective in preventing halothane-epinephrine arrhythmias, but selective beta 2 blockade is not.
Author List
Hayashi Y, Sumikawa K, Kamibayashi T, Yamatodani A, Mammoto T, Kuro M, Yoshiya IAuthor
Tadanori Mammoto MD, PhD Associate Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adrenergic beta-AntagonistsAnimals
Arrhythmias, Cardiac
Blood Pressure
Cardiac Complexes, Premature
Dogs
Dose-Response Relationship, Drug
Epinephrine
Female
Halothane
Heart Rate
Male
Metoprolol
Propanolamines