Faculty Collaboration Database

Hydroxocobalamin for Vasoplegic Syndrome in Liver Transplantation: Restoration of Blood Pressure Without Vasospasm. A A Case Rep 2016 Dec 15;7(12):247-250

Date

10/18/2016

Pubmed ID

27749291

DOI

10.1213/XAA.0000000000000398

Scopus ID

2-s2.0-85018872675   13 Citations

Abstract

Systemic vasoplegia is common in patients undergoing liver transplantation. In this report, we present a case in which treatment with conventional vasopressors caused peripheral arterial spasm, rendering arterial blood pressure monitoring impossible. Administration of methylene blue resolved the vasospasm; however, concern for toxic dose requirements limited its use. Hydroxocobalamin administration resolved the vasospasm and increased blood pressure without the potential adverse effects seen with methylene blue. This case represents the first report of hydroxocobalamin use in liver transplantation and may represent a new option for the treatment of vasoplegia and the potential vasospasm that may result from traditional vasopressors.

Author List

Woehlck HJ, Boettcher BT, Lauer KK, Cronin DC, Hong JC, Zimmerman MA, Kim J, Selim M

Authors

Brent Boettcher DO Assistant Professor in the Anesthesiology department at Medical College of Wisconsin
Joohyun Kim MD, PhD Associate Professor in the Surgery department at Medical College of Wisconsin
Kathryn K. Lauer MD Vice Chair, Professor in the Anesthesiology department at Medical College of Wisconsin
Motaz Selim MBBS, MSc, MD, PhD Assistant Professor in the Surgery department at Medical College of Wisconsin
Harvey J. Woehlck MD Professor in the Anesthesiology department at Medical College of Wisconsin
Michael A. Zimmerman MD, FACS Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Blood Pressure
Female
Humans
Hydroxocobalamin
Liver Transplantation
Methylene Blue
Middle Aged
Peripheral Arterial Disease
Treatment Outcome
Vascular Resistance
Vasoplegia