Hydroxocobalamin for Vasoplegic Syndrome in Liver Transplantation: Restoration of Blood Pressure Without Vasospasm. A A Case Rep 2016 Dec 15;7(12):247-250
Date
10/18/2016Pubmed ID
27749291DOI
10.1213/XAA.0000000000000398Scopus ID
2-s2.0-85018872675 (requires institutional sign-in at Scopus site) 22 CitationsAbstract
Systemic vasoplegia is common in patients undergoing liver transplantation. In this report, we present a case in which treatment with conventional vasopressors caused peripheral arterial spasm, rendering arterial blood pressure monitoring impossible. Administration of methylene blue resolved the vasospasm; however, concern for toxic dose requirements limited its use. Hydroxocobalamin administration resolved the vasospasm and increased blood pressure without the potential adverse effects seen with methylene blue. This case represents the first report of hydroxocobalamin use in liver transplantation and may represent a new option for the treatment of vasoplegia and the potential vasospasm that may result from traditional vasopressors.
Author List
Woehlck HJ, Boettcher BT, Lauer KK, Cronin DC, Hong JC, Zimmerman MA, Kim J, Selim MAuthors
Brent Boettcher DO Associate Professor in the Anesthesiology department at Medical College of WisconsinKathryn K. Lauer MD Vice Chair, Professor in the Anesthesiology department at Medical College of Wisconsin
Harvey J. Woehlck MD Professor in the Anesthesiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Blood PressureFemale
Humans
Hydroxocobalamin
Liver Transplantation
Methylene Blue
Middle Aged
Peripheral Arterial Disease
Treatment Outcome
Vascular Resistance
Vasoplegia
