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Common and dissociable prefrontal loci associated with component mechanisms of analogical reasoning. Cereb Cortex 2010 Mar;20(3):524-33

Date

06/25/2009

Pubmed ID

19549622

DOI

10.1093/cercor/bhp121

Scopus ID

2-s2.0-76749149970   75 Citations

Abstract

The ability to draw analogies requires 2 key cognitive processes, relational integration and resolution of interference. The present study aimed to identify the neural correlates of both component processes of analogical reasoning within a single, nonverbal analogy task using event-related functional magnetic resonance imaging. Participants verified whether a visual analogy was true by considering either 1 or 3 relational dimensions. On half of the trials, there was an additional need to resolve interference in order to make a correct judgment. Increase in the number of dimensions to integrate was associated with increased activation in the lateral prefrontal cortex as well as lateral frontal pole in both hemispheres. When there was a need to resolve interference during reasoning, activation increased in the lateral prefrontal cortex but not in the frontal pole. We identified regions in the middle and inferior frontal gyri which were exclusively sensitive to demands on each component process, in addition to a partial overlap between these neural correlates of each component process. These results indicate that analogical reasoning is mediated by the coordination of multiple regions of the prefrontal cortex, of which some are sensitive to demands on only one of these 2 component processes, whereas others are sensitive to both.

Author List

Cho S, Moody TD, Fernandino L, Mumford JA, Poldrack RA, Cannon TD, Knowlton BJ, Holyoak KJ

Author

Leonardo Fernandino PhD Assistant Professor in the Neurology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Attention
Brain Mapping
Concept Formation
Executive Function
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Oxygen
Pattern Recognition, Visual
Photic Stimulation
Prefrontal Cortex
Reaction Time
Young Adult