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Identification of High-risk Cryptic CRLF2 Rearrangements in B-Cell Acute Lymphoblastic Leukemia Utilizing an FGFR3/IGH Dual-Color Dual-Fusion DNA Probe Set. J Pediatr Hematol Oncol 2017 05;39(4):e207-e210

Date

11/08/2016

Pubmed ID

27820126

DOI

10.1097/MPH.0000000000000691

Abstract

B-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood malignancy with gene rearrangements involving the IGH locus occurring in ∼5% of cases. Fluorescence in situ hybridization (FISH) probes targeting the IGH locus are not included in the standard children's oncology group (COG) fluorescence in situ hybridization panel. At our institute, we incorporated the use of FGFR3/IGH dual-color dual-fusion DNA probes for confirmation of aneuploidy 4 and 14 in diagnostic B-ALL specimens. Subsequently we have identified 4 B-ALL cases with cryptic CRLF2-IGH translocations that would otherwise have gone undetected. Detection of genetic alterations in B-ALL, such as CRLF2 rearrangements, may enhance patient risk stratification and therapy options in pediatric B-ALL.

Author List

Robin AJ, Peterson JF, Grignon JW Jr, Gheorghe G, Burke MJ, vanTuinen P

Author

Michael James Burke MD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Child
Child, Preschool
DNA Probes
Female
Gene Rearrangement
Humans
Immunoglobulin Heavy Chains
In Situ Hybridization, Fluorescence
Infant
Male
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Receptor, Fibroblast Growth Factor, Type 3
Receptors, Cytokine
Risk
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a