Identification of High-risk Cryptic CRLF2 Rearrangements in B-Cell Acute Lymphoblastic Leukemia Utilizing an FGFR3/IGH Dual-Color Dual-Fusion DNA Probe Set. J Pediatr Hematol Oncol 2017 May;39(4):e207-e210
Date
11/08/2016Pubmed ID
27820126DOI
10.1097/MPH.0000000000000691Scopus ID
2-s2.0-84994577405 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
B-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood malignancy with gene rearrangements involving the IGH locus occurring in ∼5% of cases. Fluorescence in situ hybridization (FISH) probes targeting the IGH locus are not included in the standard children's oncology group (COG) fluorescence in situ hybridization panel. At our institute, we incorporated the use of FGFR3/IGH dual-color dual-fusion DNA probes for confirmation of aneuploidy 4 and 14 in diagnostic B-ALL specimens. Subsequently we have identified 4 B-ALL cases with cryptic CRLF2-IGH translocations that would otherwise have gone undetected. Detection of genetic alterations in B-ALL, such as CRLF2 rearrangements, may enhance patient risk stratification and therapy options in pediatric B-ALL.
Author List
Robin AJ, Peterson JF, Grignon JW Jr, Gheorghe G, Burke MJ, vanTuinen PAuthor
Michael James Burke MD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
ChildChild, Preschool
DNA Probes
Female
Gene Rearrangement
Humans
Immunoglobulin Heavy Chains
In Situ Hybridization, Fluorescence
Infant
Male
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Receptor, Fibroblast Growth Factor, Type 3
Receptors, Cytokine
Risk
