Vasopressin and blood pressure regulation. Clin Physiol Biochem 1988;6(3-4):150-62
Date
01/01/1988Pubmed ID
3060296Scopus ID
2-s2.0-0023943668 (requires institutional sign-in at Scopus site) 34 CitationsAbstract
The vasoconstrictor actions of arginine vasopressin (AVP) have been shown to occur in concentrations much lower than previously thought. Pressor responses to AVP are a poor index of vasoconstrictor activity since, in contrast to other vasoconstrictor agents, the expected rise of pressure is offset by dose-dependent decreases of cardiac output. The mechanisms for this appear to be, in large part, modulation of the autonomic nervous system whereby AVP enhances vagal nerve activity and reduces peripheral sympathetic nerve activity. AVP enhancement of baroreceptor reflex gain is in part responsible for these changes in some species (dog and rabbit), but not in others (rat). The release of AVP appears to contribute significantly to the normalization of arterial pressure in volume-depleted and hypotensive states. The link between plasma AVP and hypertension remains unclear, but it appears likely that it has an important permissive action in the development of sodium-dependent forms of hypertension.
Author List
Cowley AW JrAuthor
Allen W. Cowley Jr PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAutonomic Nervous System
Blood Pressure
Cats
Dogs
Female
Humans
Hypertension
Hypotension
Male
Pressoreceptors
Rats
Vasoconstrictor Agents
Vasopressins
