Faculty Collaboration Database

Perspective on the physiology of hypertension. Cardiovasc Clin 1978;9(1):1-22

Date

01/01/1978

Pubmed ID

352514

Scopus ID

2-s2.0-0018199484 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

Present understanding of the physiology of arterial pressure regulation indicates that the renal-body fluid volume system determines the level at which the mean pressure resides over long periods of time. The relationships between blood volume, and size and compliance of the entire vascular system, and intrinsic regulation of tissue blood flow determine the sequence of observed changes in cardiac output and total peripheral resistance. Current evidence is compatible with the concept that functional changes in the renal vasculature or tubular system, either intrinsic or extrinsic in origin, reflect the final common pathway in the genesis of all forms of experimental and human hypertension. At the present time the nature of these renal changes appears to alter the fundamental relationships between renal perfusion pressure and sodium and water excretion. One of the major challenges in the field of hypertension today is to test the hypothesis that changes in renal function, either extrinsic or intrinsic in form, are involved in all forms of hypertension.

Author List

Cowley AW Jr

Author

Allen W. Cowley Jr PhD Professor in the Physiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Angiotensin II
Animals
Blood Pressure
Blood Vessels
Body Water
Cardiac Output
Chemoreceptor Cells
Dogs
Heart
Humans
Hypertension
Kidney
Male
Mechanoreceptors
Rats
Reflex
Renin
Vascular Resistance
Vasopressins