Medical College of Wisconsin
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Immune-Mediated Diseases of the Central Nervous System: A Specificity-Focused Diagnostic Paradigm. Pediatr Clin North Am 2017 Feb;64(1):57-90

Date

11/30/2016

Pubmed ID

27894452

DOI

10.1016/j.pcl.2016.08.005

Scopus ID

2-s2.0-84999015171 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

Immune-mediated diseases of the central nervous system show wide variability both symptomatically and with respect to underlying pathophysiology. Recognizing aberrant immunologic activity as the cause of neurologic dysfunction requires establishing as precise a neuroanatomic and functional phenotype as possible, and a diagnostic and therapeutic strategy that stabilizes the patient, excludes broad categories of disease via rapidly available diagnostic assays, and maintains a broad differential diagnosis that includes immune-mediated conditions. This process is aided by recognizing the appropriate clinical circumstances under which immune-mediated disease should be suspected, and how to differentiate these conditions from other causes of similar neurologic dysfunction.

Author List

Co DO, Bordini BJ, Meyers AB, Inglese C

Author

Brett J. Bordini MD Associate Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Autoimmune Diseases of the Nervous System
Child
Delayed Diagnosis
Diagnosis, Differential
Humans
Phenotype
Rare Diseases