Immune-Mediated Diseases of the Central Nervous System: A Specificity-Focused Diagnostic Paradigm. Pediatr Clin North Am 2017 Feb;64(1):57-90
Date
11/30/2016Pubmed ID
27894452DOI
10.1016/j.pcl.2016.08.005Scopus ID
2-s2.0-84999015171 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Immune-mediated diseases of the central nervous system show wide variability both symptomatically and with respect to underlying pathophysiology. Recognizing aberrant immunologic activity as the cause of neurologic dysfunction requires establishing as precise a neuroanatomic and functional phenotype as possible, and a diagnostic and therapeutic strategy that stabilizes the patient, excludes broad categories of disease via rapidly available diagnostic assays, and maintains a broad differential diagnosis that includes immune-mediated conditions. This process is aided by recognizing the appropriate clinical circumstances under which immune-mediated disease should be suspected, and how to differentiate these conditions from other causes of similar neurologic dysfunction.
Author List
Co DO, Bordini BJ, Meyers AB, Inglese CAuthor
Brett J. Bordini MD Associate Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Autoimmune Diseases of the Nervous SystemChild
Delayed Diagnosis
Diagnosis, Differential
Humans
Phenotype
Rare Diseases