Medical College of Wisconsin
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Pre-analytical issues for testosterone and estradiol assays. Steroids 2008 Dec 12;73(13):1297-304

Date

07/01/2008

Pubmed ID

18589466

DOI

10.1016/j.steroids.2008.05.005

Scopus ID

2-s2.0-54149107049   18 Citations

Abstract

In order to standardize and harmonize testosterone measurement, it is vital to identify and minimize pre-analytical error as well as standardize them when developing reference intervals. These pre-analytic issues can be separated into technical and biological factors. Technical factors to address are the type of sample (serum vs. plasma), the type of collection tube, and the processing, storage, and handling of the samples. Biological issues include addressing the age of the subject, the time of day and month the sample is drawn, and all of the possible interfering drugs the subject may be taking. We recommend that great attention be paid to these pre-analytical issues before the assay methodologies are harmonized.

Author List

Raff H, Sluss PM

Author

Hershel Raff PhD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Clinical Chemistry Tests
Estradiol
Female
Humans
Male
Periodicity
Quality Control
Reference Standards
Reference Values
Specimen Handling
Testosterone
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d