Faculty Collaboration Database

Acidic polyanion poly(acrylic acid) prevents calcium oxalate crystal deposition. Kidney Int 2008 Oct;74(7):919-24

Date

06/20/2008

Pubmed ID

18563053

Pubmed Central ID

PMC2566899

DOI

10.1038/ki.2008.253

Scopus ID

2-s2.0-51849085221 (requires institutional sign-in at Scopus site)   18 Citations

Abstract

Acidic macromolecules inhibit calcium oxalate nucleation, growth, aggregation and attachment to cells in vitro. To test for such an effect in vivo we used osmotic minipumps to continuously infuse several doses of the 5.1 kDa poly(acrylic acid) (pAA(5.1)) into rats fed a diet which causes renal calcium oxalate crystal deposition. Although kidneys of rats receiving the saline control contained calcium oxalate crystals, measured by polarized light microscopy, those of animals given pAA(5.1) had significantly lower numbers of crystals in various zones of the kidney. Delivery of pAA(5.1) to urine was confirmed by measuring excretion of infused biotinylated pAA(5.1). Both the derivatized and unlabelled pAA(5.1) had the same effects on crystallization in vitro. Our study shows that acidic polymers hold promise as effective therapies for kidney stones likely through prevention of calcium oxalate crystal aggregate formation.

Author List

Kleinman JG, Alatalo LJ, Beshensky AM, Wesson JA

Author

Jeffrey A. Wesson MD, PhD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Acrylic Resins
Animals
Calcium Oxalate
Crystallization
Kidney Calculi
Male
Polyelectrolytes
Polymers
Rats
Rats, Sprague-Dawley
Urine