Outcome disparities between African Americans and Caucasians in contemporary kidney transplant recipients. Am J Surg 2017 Apr;213(4):666-672
Date
11/27/2016Pubmed ID
27887677Pubmed Central ID
PMC5373991DOI
10.1016/j.amjsurg.2016.11.024Scopus ID
2-s2.0-85006998162 (requires institutional sign-in at Scopus site) 33 CitationsAbstract
BACKGROUND: Racial disparities in African-American (AA) kidney transplant have persisted for nearly 40 years, with limited data available on the scope of this issue in the contemporary era of transplantation.
METHODS: Descriptive retrospective cohort study of US registry data including adult solitary kidney transplants between Jan 1, 2005 to Dec 31, 2009.
RESULTS: 60,695 recipients were included; 41,426 Caucasians (68%) and 19,269 AAs (32%). At baseline, AAs were younger, had lower college graduation rates, were more likely to be receiving public health insurance and have diabetes. At one-year post-transplant, AAs had 62% higher risk of graft loss (RR 1.62, 95% CI 1.50-1.75) which increased to 93% at five years (RR 1.93, 95% CI 1.85-2.01). Adjusted risk of graft loss, accounting for baseline characteristics, was 60% higher in AAs (HR 1.61 [1.52-1.69]). AAs had significantly higher risk of acute rejection and delayed graft function.
CONCLUSION: AAs continue to experience disproportionately high rates of graft loss within the contemporary era of transplant, which are related to a convergence of an array of socioeconomic and biologic risk factors.
Author List
Taber DJ, Egede LE, Baliga PKAuthor
Leonard E. Egede MD Center Director, Chief, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Age DistributionBody Mass Index
Cohort Studies
Creatinine
Delayed Graft Function
Diabetes Mellitus
Educational Status
Female
Graft Rejection
Humans
Hypertension
Kidney Transplantation
Male
Medical Assistance
Middle Aged
Retrospective Studies
Transplant Recipients
United States
