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Serum Amyloid A as a Surrogate Marker for Mucosal and Histologic Inflammation in Patients with Crohn's Disease. Inflamm Bowel Dis 2017 01;23(1):158-164

Date

12/09/2016

Pubmed ID

27930409

DOI

10.1097/MIB.0000000000000991

Scopus ID

2-s2.0-85002057652   25 Citations

Abstract

BACKGROUND: Serum amyloid A (SAA) is an acute-phase protein, but its role as a biomarker of disease activity in Crohn's disease is unclear. The aim of the study was to assess the correlation between SAA, inflammatory cytokines, and mucosal inflammation in patients with Crohn's disease and to investigate whether this marker might be useful in patients who do not have elevated C-reactive protein (CRP) levels despite having active disease.

METHODS: Cross-sectional study including patients with Crohn's disease who underwent colonoscopies for assessment of disease activity. Predictive variables were recorded at the time of the procedure and included demographics, phenotype of disease, medications, and collection of serum for cytokine analysis (SAA, CRP, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and interleukins 8, 1β, and 6). The primary outcome was the presence of mucosal healing (MH) (absence of macroscopic and microscopic inflammation).

RESULTS: Ninety-four patients were included. Sixty-eight (72.3%) had not achieved MH. SAA, CRP, intercellular adhesion molecule, and interleukin-6 levels were significantly lower in those patients with MH. SAA was the only test that performed well in the sensitivity/specificity analysis (receiver operating characteristic: 0.81, P = 0.046). A high SAA was able to identify 70% of the patients with a normal CRP but active inflammation.

CONCLUSIONS: High circulating SAA levels can correlate with lack of MH and may be used as a surrogate marker for disease activity, even in those patients in whom CRP levels do not correlate with disease activity.

Author List

Yarur AJ, Quintero MA, Jain A, Czul F, Barkin JS, Abreu MT

Author

Andres Jose Yarur MD Associate Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Biomarkers
C-Reactive Protein
Colonoscopy
Crohn Disease
Cross-Sectional Studies
Female
Humans
Inflammation
Intestinal Mucosa
Male
Middle Aged
Phenotype
Predictive Value of Tests
Prospective Studies
ROC Curve
Sensitivity and Specificity
Serum Amyloid A Protein
Severity of Illness Index
Young Adult