siRNA Therapy, Challenges and Underlying Perspectives of Dendrimer as Delivery Vector. Curr Pharm Des 2015;21(31):4614-36
Date
10/22/2015Pubmed ID
26486147DOI
10.2174/138161282131151013192116Scopus ID
2-s2.0-84946718579 (requires institutional sign-in at Scopus site) 62 CitationsAbstract
siRNA technology presents a helpful means of gene silencing in mammalian cells. Advancement in the field includes enhanced attentiveness in the characterization of target and off-target effects employing suitable controls and gene expression microarrays. These will permit expansion in the measurement of single and multiple target combinations and also permit comprehensive efforts to understand mammalian cell processes. Another fact is that the delivery of siRNA requires the creation of a nanoparticulate vector with controlled structural geometry and surface modalities inside the targeted cells. On the other hand, dendrimers represent the class of carrier system where massive control over size, shape and physicochemical properties makes this delivery vector exceptional and favorable in genetic transfection applications. The siRNA therapeutics may be incorporated inside the geometry of the density controlled dendrimers with the option of engineering the structure to the specific needs of the genetic material and its indication. The existing reports on the siRNA carrying and deliverance potential of dendrimers clearly suggest the significance of this novel class of polymeric architecture and certainly elevate the futuristic use of this highly branched vector as genetic material delivery system.
Author List
Tekade RK, Maheshwari RG, Sharma PA, Tekade M, Chauhan ASAuthor
Abhay Chauhan PhD Associate Professor in the School of Pharmacy Administration department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsDendrimers
Gene Silencing
Gene Transfer Techniques
Genetic Vectors
Humans
Nanoparticles
Polymers
RNA Interference
RNA, Small Interfering
