Medical College of Wisconsin
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Controlled systemic delivery of indomethacin using membrane-moderated, cream formulation-based transdermal devices. Drug Deliv 2006;13(3):207-13

Date

03/25/2006

Pubmed ID

16556573

DOI

10.1080/10717540500309172

Scopus ID

2-s2.0-33645285564 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

The present study was carried out to design a viable and practically effective transdermal systems of indomethacin using cream-based drug reservoirs and suitable rate controlling membranes. As vehicles, a more lipophilic base (F(1)) and a cream formulation containing predominant aqueous phase (F(2)) were chosen to study the influence of vehicle nature and role of permeation enhancers that increases thermodynamic activity and to provide diffusible species of drug to skin. Rate controlling membranes of cellulose acetate (CA) and ethyl cellulose (EC) with polyvinyl pyrollidine and hydroxypropyl methyl cellulose were used to design transdermal devices. In vivo, effective plasma concentrations of indomethacin are maintained up to 24 hr whereas oral formulation showed only up to 8 hr. Although the plasma drug levels between both EC films differ insignificantly, PVP film showed a better pharmacokinetic profile. The pharmacodynamic performance of the transdermal devices exhibited good anti-inflammatory activity over 24 hr compared with orally administered indomethacin. In vivo studies indicate the superiority of CA films over the EC films. Further, enhancement may be achieved with other classic enhancers/enhancement strategies with such devices containing aqueous cream vehicle and the optimum membranes.

Author List

Rao PR, Chalasani KB, Chauhan AS, Jain AK, Diwan PV, Ram MK

Author

Abhay Chauhan PhD Associate Professor in the School of Pharmacy Administration department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Administration, Cutaneous
Administration, Oral
Animals
Anti-Inflammatory Agents, Non-Steroidal
Area Under Curve
Cellulose
Delayed-Action Preparations
Drug Delivery Systems
Edema
Emulsions
Hypromellose Derivatives
In Vitro Techniques
Indomethacin
Male
Membranes, Artificial
Methylcellulose
Polyvinyls
Pyrrolidines
Rats
Rats, Wistar
Skin
Skin Absorption
Stomach Ulcer