Faculty Collaboration Database

The extrapolated reference values procedure: Theory, algorithm, and results in patients and control subjects. Muscle Nerve 2018 Jan;57(1):90-95

Date

02/10/2017

Pubmed ID

28181271

DOI

10.1002/mus.25606

Scopus ID

2-s2.0-85017658889 (requires institutional sign-in at Scopus site)   15 Citations

Abstract

INTRODUCTION: Reference values (RVs) are required to separate normal from abnormal values obtained in electrodiagnostic (EDx) testing. However, it is frequently impractical to perform studies on control subjects to obtain RVs. The Extrapolated Reference Values (E-Ref) procedure extracts RVs from data obtained during clinically indicated EDx testing. We compared the E-Ref results with established RVs in several sets of EDx data.

METHODS: The mathematical basis for E-Ref was explored to develop an algorithm for the E-Ref procedure. To test the validity of this algorithm, it was applied to simulated and real jitter measurements from control subjects and patients with myasthenia gravis, and to nerve conduction studies from patients with various conditions referred for EDx studies.

RESULTS: There was good concordance between E-Ref and RVs for all evaluated data sets.

DISCUSSION: E-Ref is a promising method to develop RVs. Muscle Nerve 57: 90-95, 2018.

Author List

Nandedkar SD, Sanders DB, Hobson-Webb LD, Billakota S, Barkhaus PE, Stålberg EV

Author

Paul E. Barkhaus MD Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Algorithms
Data Interpretation, Statistical
Electrodiagnosis
Electromyography
Female
Humans
Male
Middle Aged
Myasthenia Gravis
Neural Conduction
Normal Distribution
Reference Values
Reproducibility of Results