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Vocal fold paralysis in preterm infants: prevalence and analysis of risk factors. J Perinatol 2017 May;37(5):585-590



Pubmed ID




Scopus ID

2-s2.0-85009948950   7 Citations


OBJECTIVE: To calculate the prevalence of vocal fold paralysis (VFP) in preterm (<37 weeks of gestation) infants at a single neonatal intensive care unit (NICU) and identify risk factors for the development of VFP.

STUDY DESIGN: This is a case control study of all surviving preterm infants admitted to the NICU at Children's Hospital of Wisconsin from 2006 to 2012, comparing those with and without VFP. Multivariate analysis was performed to identify significant risk factors for VFP.

RESULTS: Of the 2083 patients included, 73 (3.5%) had VFP, including 18% of those at <26 weeks of gestation. On multivariate analyses, VFP was associated with patent ductus arteriosus (PDA) ligation (P<0.001, odds ratio (OR) 15.9, 95% confidence interval (CI) 8.9 to 28.1), history of invasive ventilation (P=0.008, OR 4.5, 95% CI 1.5 to 13.6) and black vs non-black race (P=0.001, OR 2.5, 95% CI 1.5 to 4.3).

CONCLUSION: Given the prevalence of VFP and its associated morbidity, efforts to decrease PDA ligation and invasive ventilation in preterm infants are warranted.

Author List

Jabbour J, Uhing M, Robey T


Thomas C. Robey MD Professor in the Otolaryngology department at Medical College of Wisconsin
Michael R. Uhing MD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Case-Control Studies
Ductus Arteriosus, Patent
Gestational Age
Hospitals, Pediatric
Infant, Extremely Premature
Infant, Newborn
Intensive Care Units, Neonatal
Logistic Models
Multivariate Analysis
Respiration, Artificial
Risk Factors
Vocal Cord Paralysis