Are there several types of colorectal carcinomas? Correlations with genetic data. Eur J Cancer Prev 1999 Dec;8 Suppl 1:S13-20
Date
04/20/2000Pubmed ID
10772413Scopus ID
2-s2.0-0033505155 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
Molecular studies have shown that different genetic pathways are involved in the history of colorectal carcinomas. This suggests that a correlation exists between the molecular, clinical and pathological features of tumours. Two large groups can be individualized: the first group is characterized by allelic losses and hyperdiploidy. These LOH (for loss of heterozygosity)-positive tumours represent 80% of colorectal carcinomas. Among them more than two-thirds are located in the distal colon. They have the worst prognosis. The second group has a normal diploid pattern and a phenotypic microsatellite instability without allelic losses. These tumours represent 10-15% of all colorectal carcinomas and about 30% of the right-sided tumours. They are associated with a better prognosis. In the future, it would perhaps be better to classify colorectal carcinomas according to their molecular features rather than to their topographical localizations.
Author List
Martin L, Assem M, Piard FAuthor
Mahfoud Assem PharmD Associate Professor in the School of Pharmacy Administration department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
CarcinomaColorectal Neoplasms
Female
Genes, p53
Genetic Markers
Genetic Predisposition to Disease
Humans
Incidence
Male
Microsatellite Repeats
Mutation
Prognosis
Risk Factors
Sensitivity and Specificity
Survival Rate
