Hypoxia increases vasodilator release from internal mammary artery and saphenous vein grafts. Ann Thorac Surg 1998 May;65(5):1220-5
Date
05/22/1998Pubmed ID
9594841DOI
10.1016/s0003-4975(98)00096-4Scopus ID
2-s2.0-0032076017 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
BACKGROUND: Greater release of endothelium-derived nitric oxide is implicated in the superior patency of the internal mammary artery (IMA) used in coronary artery bypass grafting. This study compared the release of endothelium-derived nitric oxide into the lumen of the IMA and the saphenous vein under normoxic versus hypoxic conditions.
METHODS: Segments of canine IMA and saphenous vein were perfused in vitro. Vasorelaxant activity was measured as vasodilatation of coronary artery smooth muscle induced by the effluent.
RESULTS: Effluents from the IMA and saphenous vein caused comparable vasodilation of coronary artery smooth muscle. The vasodilatation reversed when perfusion was switched to a prosthetic conduit. Vasodilator activity from the IMA and saphenous vein was attenuated by removing the intima of the grafts or by adding N(G)-monomethyl-L-arginine (10(-4) mol/L) or N(G)-nitro-L-arginine (10(-4) mol/L), two inhibitors of nitric oxide synthesis. Indomethacin attenuated vasorelaxant activity from saphenous vein grafts but not IMA grafts (n = 10). Vasodilator release from the IMA and saphenous vein was augmented by hypoxia. This augmentation was inhibited by indomethacin (n = 10, p < 0.05). Hypoxic augmentation reversed with return to normoxia.
CONCLUSIONS: The release of endothelium-derived nitric oxide and prostacyclin from bypass grafts into the lumen, particularly during hypoxemia, could promote the vasodilation of distal coronary arterial beds, enhancing myocardial perfusion.
Author List
Pearson PJ, Evora PR, Discigil B, Schaff HVAuthor
Paul Joseph Pearson MD, PhD Chief, Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCoronary Artery Bypass
Coronary Circulation
Cyclooxygenase Inhibitors
Dogs
Endothelium, Vascular
Enzyme Inhibitors
Epoprostenol
Hypoxia
Indomethacin
Mammary Arteries
Muscle, Smooth, Vascular
Nitric Oxide
Nitroarginine
Platelet Aggregation Inhibitors
Saphenous Vein
Tunica Intima
Vascular Patency
Vasodilation
omega-N-Methylarginine