Endothelium-derived contracting factors. Changgeng Yi Xue Za Zhi 1993 Sep;16(3):140-53
Date
09/01/1993Pubmed ID
8221287Scopus ID
2-s2.0-0027420970 (requires institutional sign-in at Scopus site)Abstract
In the past decade, the importance of endothelium in modulating vascular tone has become apparent. Endothelium can produce different vasodilators, such as prostacyclin, endothelium-derived relaxing factor (most likely nitric oxide), and endothelium-derived hyperpolarizing factor. Endothelium can also produce endothelium-derived contracting factors (EDCF) which can induce constriction of the underlying vascular smooth muscle. Constriction may be mediated by a variety of products released by the endothelium. Thus, by responding to various stimuli and releasing either relaxing or contracting factors, the endothelium can set and modulate vascular tone.
Author List
Lin PJ, Pearson PJ, Chang CHAuthor
Paul Joseph Pearson MD, PhD Chief, Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCalcium
Endothelins
Endothelium, Vascular
Humans
Hypoxia
Nitric Oxide
Superoxides
Vasoconstriction
