Endothelium-derived relaxing factors. Changgeng Yi Xue Za Zhi 1993 Mar;16(1):1-13
Date
03/01/1993Pubmed ID
8098260Scopus ID
2-s2.0-0027262350 (requires institutional sign-in at Scopus site) 1 CitationAbstract
The endothelium modulates vascular tone by liberating both dilator [endothelium-derived relaxing factors; EDRFs]and constrictor substances [endothelium-derived contracting factors; EDCFs]. This review focused on endothelium-derived relaxing factor, its discovery, characteristics, synthesis and interaction with vascular smooth muscle. The major endothelium-derived relaxing factor is nitric oxide formed from L-arginine, which activates guanylate cyclase in the smooth muscle, leading to accumulation of cyclic-GMP. Endothelial cells can also release endothelium-derived hyperpolarizing factor EDHF which also cause endothelium-dependent relaxation.
Author List
Lin PJ, Pearson PJ, Chang CHAuthor
Paul Joseph Pearson MD, PhD Chief, Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsEndothelium, Vascular
Free Radicals
Guanylate Cyclase
Humans
Muscle, Smooth, Vascular
Nitric Oxide
