Faculty Collaboration Database

Association of psoriasis and psoriatic arthritis with osteoporosis and pathological fractures. J Am Acad Dermatol 2017 Jun;76(6):1045-1053.e3

Date

03/21/2017

Pubmed ID

28314685

DOI

10.1016/j.jaad.2016.11.046

Scopus ID

2-s2.0-85019482841 (requires institutional sign-in at Scopus site)   47 Citations

Abstract

BACKGROUND: Previous studies examining the relationship between psoriasis (Pso), osteoporosis, and pathological fractures found conflicting results.

OBJECTIVE: To determine whether Pso and psoriatic arthritis (PsA) are associated with osteoporosis and fractures in US adults.

METHODS: Cross-sectional study of 198,102,435 children and adults, including 183,725 with Pso and 28,765 with PsA from the 2006-2012 National Emergency Department Sample, including 20% of the emergency care visits throughout the United States.

RESULTS: In a pooled analysis across all 7 years, patients with Pso had significantly higher odds (multivariate logistic regression; odds ratio, 95% confidence intervals) of diagnosis with osteopenia (2.86, 2.70-3.02), osteoporosis (2.97, 2.89-3.06), osteomalacia (4.40, 2.50-7.74), ankylosing spondylitis (13.34, 12.02-14.81), and pathological fractures (2.35, 2.19-2.53). Similar associations were observed for PsA. Pso was also associated with vertebral (1.17, 1.09-1.25), pelvic (1.18, 1.06-1.31), femoral (1.68, 1.60-1.78), and tibial/fibular fractures (1.28, 1.16-1.41). Whereas, PsA was associated with stress (2.87, 1.08-7.64) and vertebral (1.45, 1.24-1.70), pelvic (1.75, 1.41-2.18), femoral (2.07, 1.85-2.32), and tibial/fibular (1.60, 1.28-2.01) fractures.

LIMITATIONS: Data on severity and treatments of Pso were not available.

CONCLUSION: Pso and PsA were associated with osteopenia, osteoporosis, ankylosing spondylitis, and pathologic fractures.

Author List

Kathuria P, Gordon KB, Silverberg JI

Author

Kenneth Brian Gordon MD Chair, Professor in the Dermatology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Aged, 80 and over
Arthritis, Psoriatic
Cross-Sectional Studies
Female
Fractures, Spontaneous
Humans
Male
Middle Aged
Osteoporosis
Psoriasis
Risk Assessment
Young Adult