Faculty Collaboration Database

Natural Killer T Cells in Liver Ischemia-Reperfusion Injury. J Clin Med 2017 Apr 01;6(4)

Date

04/04/2017

Pubmed ID

28368299

Pubmed Central ID

PMC5406773

DOI

10.3390/jcm6040041

Abstract

Restoration of blood flow to an ischemic organ results in significant tissue injury. In the field of liver transplantation, ischemia-reperfusion injury (IRI) has proven to be a formidable clinical obstacle. In addition to metabolic stress and inflammation, IRI results in profound graft dysfunction and loss. The severity of IRI further limits the ability to expand the donor pool by using partial grafts and marginal organs. As such, the inflammatory response to reperfusion of the liver continues to be an area of intense investigation. Among the various leukocytes involved in IRI, new insights suggest that natural killer T (NKT) cells may be a central driver of hepatocellular injury. Herein, we examine recent experimental observations that provide a mechanistic link between NKT cell recruitment to liver and post-perfusion tissue injury.

Author List

Zimmerman MA, Martin A, Yee J, Schiller J, Hong JC

Author

Michael A. Zimmerman MD, FACS Professor in the Surgery department at Medical College of Wisconsin