Natural Killer T Cells in Liver Ischemia-Reperfusion Injury. J Clin Med 2017 Apr 01;6(4)
Date
04/04/2017Pubmed ID
28368299Pubmed Central ID
PMC5406773DOI
10.3390/jcm6040041Scopus ID
2-s2.0-85052679079 (requires institutional sign-in at Scopus site) 15 CitationsAbstract
Restoration of blood flow to an ischemic organ results in significant tissue injury. In the field of liver transplantation, ischemia-reperfusion injury (IRI) has proven to be a formidable clinical obstacle. In addition to metabolic stress and inflammation, IRI results in profound graft dysfunction and loss. The severity of IRI further limits the ability to expand the donor pool by using partial grafts and marginal organs. As such, the inflammatory response to reperfusion of the liver continues to be an area of intense investigation. Among the various leukocytes involved in IRI, new insights suggest that natural killer T (NKT) cells may be a central driver of hepatocellular injury. Herein, we examine recent experimental observations that provide a mechanistic link between NKT cell recruitment to liver and post-perfusion tissue injury.
