Faculty Collaboration Database

Association of Inflammatory Bowel Disease (IBD) with Depressive Symptoms in the United States Population and Independent Predictors of Depressive Symptoms in an IBD Population: A NHANES Study. Gut Liver 2017 Jul 15;11(4):512-519

Date

04/12/2017

Pubmed ID

28395506

Pubmed Central ID

PMC5491086

DOI

10.5009/gnl16347

Scopus ID

2-s2.0-85021833158 (requires institutional sign-in at Scopus site)   48 Citations

Abstract

BACKGROUND/AIMS: There is a paucity of population-based studies on the association between inflammatory bowel disease (IBD) and depression in the U.S. population. We sought to study this association using the National Health and Nutrition Examination Survey (NHANES) database.

METHODS: We used NHANES data from 2009 to 2010. Our study included 190,269,933 U.S. adults without IBD and 2,325,226 with IBD. We sought to determine whether IBD is an independent risk factor for depressive symptoms (DS) in the U.S. population and studied the independent predictors of DS in IBD population.

RESULTS: DS was present in 49% of the IBD population versus 23% of the non-IBD population (p<0.001). During the multivariate analysis, we found that IBD was independently associated with DS in the U.S. population (p=0.002). The independent predictors of DS in the IBD population were older age (p=0.048) and divorced/separated/widowed status (p=0.005). There was nonsignificant increase in suicidal risk in IBD population with DS versus that in non-IBD population with DS (27% vs 12%, respectively, p=0.080). Only 36% of IBD individuals with DS visited mental health professional or psychiatrist within the past year.

CONCLUSIONS: IBD is independently associated with DS in the U.S. population. Further research is warranted on risk stratification, screening and management of those with IBD who are at risk of depression.

Author List

Bhandari S, Larson ME, Kumar N, Stein D

Authors

Sanjay Bhandari MD Assistant Professor in the Medicine department at Medical College of Wisconsin
Daniel J. Stein MD Director, Associate Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Age Factors
Depression
Female
Humans
Incidence
Inflammatory Bowel Diseases
Male
Marital Status
Middle Aged
Multivariate Analysis
Nutrition Surveys
Prevalence
Risk Factors
United States
Young Adult