Faculty Collaboration Database

Postradiation-associated sclerosing mediastinitis diagnosed in fine needle aspiration specimen: A cytological-pathological correlation. Ann Diagn Pathol 2017 Apr;27:43-47

Date

03/23/2017

Pubmed ID

28325360

DOI

10.1016/j.anndiagpath.2017.01.004

Scopus ID

2-s2.0-85010460524 (requires institutional sign-in at Scopus site)

Abstract

Sclerosing mediastinitis (SM) is an aggressive fibroproliferative process in the mediastinum that may lead to encasement of mediastinal structures within a dense fibrotic mass. This disease may cause significant clinical complications, morbidity, and even mortality. The etiology and pathogenesis of SM is unclear and in more than one third of cases remains idiopathic. Among the known causes of SM, granulomatous infection is the commonest. Association of SM with radiation therapy has been rarely reported. Herein, we are reporting a case of postradiation sclerosing mediastinitis diagnosed in fine needle aspiration (FNA) specimen. To our knowledge, this is the first reported case of postradiation sclerosing mediastinitis with unusual striking intracytoplasmic glycogen accumulation. Having high index of suspicion and awareness of the fact that this entity may be also associated with radiation therapy, will be helpful in avoiding diagnostic pitfalls in FNA specimens and guiding proper clinical management.

Author List

Giorgadze T, Koizumi JH, Ronen S, Chaump M, Magro CM

Author

Tamara Giorgadze MD Professor in the Pathology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Biopsy, Fine-Needle
Cytological Techniques
Diagnosis, Differential
Glycogen
Humans
Male
Mediastinitis
Mediastinum
Middle Aged
Sclerosis