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Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: a children's oncology group study. Pediatr Blood Cancer 2014 Apr;61(4):749-52

Date

11/02/2013

Pubmed ID

24178953

Pubmed Central ID

PMC3946315

DOI

10.1002/pbc.24778

Scopus ID

2-s2.0-84893451918   8 Citations

Abstract

To investigate the role of insulin-like growth factor-1 (IGF-1), in localized osteosarcoma, serum levels of IGF-1, IGFBP-2, and IGFBP-3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF-1 and IGFBP-3 compared to older (P < 0.001) along with lower IGFBP-3:IGF-1 and IGFBP-2:IGF-1 ratios (P < 0.001). IGFBP-2 did not correlate with age (P = 0.16), yet IGFBP-2:IGF-1 ratios were higher in the younger population (P < 0.001). These findings show that older patients have higher concentrations of free IGF-1. None of IGF-1, IGFBP-2, nor IGFBP-3 concentrations were associated with event-free nor overall survival.

Author List

Borinstein SC, Barkauskas DA, Bernstein M, Goorin A, Gorlick R, Krailo M, Schwartz CL, Wexler LH, Toretsky JA

Author

Cindy L. Schwartz MD, MPH Chief, Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Age Factors
Antineoplastic Combined Chemotherapy Protocols
Biomarkers, Tumor
Bone Neoplasms
Child
Child, Preschool
Female
Follow-Up Studies
Humans
Infant
Infant, Newborn
Insulin-Like Growth Factor Binding Protein 2
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Male
Osteosarcoma
Prognosis
Prospective Studies
Survival Rate
jenkins-FCD Prod-461 7d7c6113fc1a2757d2947d29fae5861c878125ab