Medical College of Wisconsin
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The management of Hodgkin disease in the young child. Curr Opin Pediatr 2003 Feb;15(1):10-6

Date

01/25/2003

Pubmed ID

12544266

DOI

10.1097/00008480-200302000-00003

Scopus ID

2-s2.0-0037305984   25 Citations

Abstract

Although childhood Hodgkin disease is sensitive to the treatment regimens devised for Hodgkin disease in adults, long-term toxicity is enhanced in the developing individual. As a result, there have been dual goals in the design of clinical trials for pediatric Hodgkin disease: 1) to reduce long-term organ injury; and 2) to increase efficacy. Radiation dose and field has been reduced by enhanced reliance on chemotherapy, thus limiting the risks of hypoplasia, hypothyroidism, secondary cancers, and valvular and atherosclerotic heart disease. Multiagent, chemotherapeutic regimens for children have been developed to avoid the risks of sterility, leukemia, and cardiopulmonary toxicity. Newer approaches advocate for early dose intensity to limit cumulative therapy using response-based paradigms. Targeting molecular mechanisms specific for the Reed-Sternberg cell may allow for less toxic and more efficacious treatments in the future.

Author List

Schwartz CL

Author

Cindy L. Schwartz MD, MPH Chief, Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Age Factors
Antineoplastic Agents
Child
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Hodgkin Disease
Humans
Time Factors
jenkins-FCD Prod-461 7d7c6113fc1a2757d2947d29fae5861c878125ab