Fine-Grained Parcellation of Brain Connectivity Improves Differentiation of States of Consciousness During Graded Propofol Sedation. Brain Connect 2017 Aug;7(6):373-381
Date
05/26/2017Pubmed ID
28540741Pubmed Central ID
PMC5685154DOI
10.1089/brain.2016.0477Scopus ID
2-s2.0-85027416134 (requires institutional sign-in at Scopus site) 17 CitationsAbstract
Conscious perception relies on interactions between spatially and functionally distinct modules of the brain at various spatiotemporal scales. These interactions are altered by anesthesia, an intervention that leads to fading consciousness. Relatively little is known about brain functional connectivity and its anesthetic modulation at a fine spatial scale. Here, we used functional imaging to examine propofol-induced changes in functional connectivity in brain networks defined at a fine-grained parcellation based on a combination of anatomical and functional features. Fifteen healthy volunteers underwent resting-state functional imaging in wakeful baseline, mild sedation, deep sedation, and recovery of consciousness. Compared with wakeful baseline, propofol produced widespread, dose-dependent functional connectivity changes that scaled with the extent to which consciousness was altered. The dominant changes in connectivity were associated with the frontal lobes. By examining node pairs that demonstrated a trend of functional connectivity change between wakefulness and deep sedation, quadratic discriminant analysis differentiated the states of consciousness in individual participants more accurately at a fine-grained parcellation (e.g., 2000 nodes) than at a coarse-grained parcellation (e.g., 116 anatomical nodes). Our study suggests that defining brain networks at a high granularity may provide a superior imaging-based distinction of the graded effect of anesthesia on consciousness.
Author List
Liu X, Lauer KK, Ward BD, Roberts CJ, Liu S, Gollapudy S, Rohloff R, Gross W, Xu Z, Chen G, Binder JR, Li SJ, Hudetz AGAuthors
Jeffrey R. Binder MD Professor in the Neurology department at Medical College of WisconsinSuneeta Gollapudy MD Associate Professor in the Anesthesiology department at Medical College of Wisconsin
William Gross MD, PhD Assistant Professor in the Anesthesiology department at Medical College of Wisconsin
Kathryn K. Lauer MD Vice Chair, Professor in the Anesthesiology department at Medical College of Wisconsin
Christopher J. Roberts MD, PhD Assistant Professor in the Anesthesiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdultBrain
Connectome
Consciousness
Female
Humans
Hypnotics and Sedatives
Magnetic Resonance Imaging
Male
Neural Pathways
Propofol
ROC Curve
Rest
Unconsciousness
Young Adult
