Faculty Collaboration Database

Using MRI to non-invasively and accurately quantify preoperative hepatic steatosis. HPB (Oxford) 2017 Aug;19(8):706-712

Date

05/22/2017

Pubmed ID

28528267

DOI

10.1016/j.hpb.2017.04.009

Scopus ID

2-s2.0-85020090602 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

BACKGROUND: The obesity epidemic has significantly increased the incidence and severity of hepatic steatosis in liver surgery patients and liver donors, potentially impacting postoperative liver regeneration and function. Development of a non-invasive means to quantify hepatic steatosis would facilitate selection of candidates for liver resection and transplant donation.

METHODS: An IRB-approved protocol prospectively enrolled 28 patients with liver tumors requiring hepatic resection. In all patients, fast dual-echo gradient-echo MR images were acquired using 2-Point Dixon technique in 2D and 3D. The degree of steatosis was quantified by percent fat fraction (%FF) from in- and out-of-phase, and water-only and fat-only images. The technique-specific %FFs were compared to intraoperative and histopathological findings.

RESULTS: For patients with >30% steatosis by histology, the mean %FF was 22% (SD ± 5.2%) compared to a mean %FF of 5.0% (SD ± 2.1%, p = 0.0001) in patients with <30% steatosis. Using scaled values for the MR-calculated %FF, all patients with >30% pathologic steatosis could be identified preoperatively.

CONCLUSIONS: Quantitative MRI identified patients with clinically-relevant steatosis with 100% accuracy. These findings could have significant impact on the management of liver resection patients and transplant donors.

Author List

Clarke CN, Choi H, Hou P, Davis CH, Ma J, Rashid A, Vauthey JN, Aloia TA

Author

Callisia N. Clarke MD Chief, Associate Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Biopsy
Feasibility Studies
Female
Humans
Liver Function Tests
Liver Neoplasms
Magnetic Resonance Imaging
Male
Middle Aged
Non-alcoholic Fatty Liver Disease
Observer Variation
Predictive Value of Tests
Prospective Studies
Reproducibility of Results
Severity of Illness Index