Angiogenesis. Pancreatology 2010;10(2-3):112-3
Date
05/13/2010Pubmed ID
20460942DOI
10.1159/000297465Scopus ID
2-s2.0-77951968538 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
The rapid growth of cancer cells, such as the case with pancreatic cancer cells, requires new blood vessel growth to sustain tumor viability. In fact, angiogenesis has been found to be closely correlated with rapid tumor growth and a poorer prognosis in pancreatic cancer. Pancreatic adenocarcinoma frequently has aberrant expression of several key regulators of angiogenesis and invasion. Via paracrine mechanisms, mutual stimulation between tumor cells and endothelial cells triggers tumor angiogenesis. In order for angiogenesis to continue, tumor cells or cells in its surrounding microenvironment must release stimulatory factors, while endothelial cells elicit a response which includes the release of proteolytic enzymes to degrade the extracellular matrix for migration and proliferation. Therefore, to extend our knowledge of the tumor microenvironment from our previous issue on the extracellular matrix, this Pancreatology and the Web article focuses on angiogenesis. and IAP.
Author List
Lomberk GAuthor
Gwen Lomberk PhD Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdenocarcinomaHumans
Internet
Neovascularization, Pathologic
Pancreatic Neoplasms
