Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Methods for measuring abdominal obesity in the prediction of severe acute pancreatitis, and their correlation with abdominal fat areas assessed by computed tomography. Aliment Pharmacol Ther 2010 Jul;32(2):244-53

Date

04/09/2010

Pubmed ID

20374222

DOI

10.1111/j.1365-2036.2010.04321.x

Scopus ID

2-s2.0-77953746704 (requires institutional sign-in at Scopus site)   35 Citations

Abstract

BACKGROUND: Obesity increases the risk for severe acute pancreatitis, although abdominal obesity may be a better prognostic marker.

AIM: To determine if a single anthropometric parameter best predicts severe acute pancreatitis and correlates with intra-abdominal fat.

METHODS: Ninety-nine patients with acute pancreatitis were studied prospectively. Anthropometry included body mass index (BMI) and girths (umbilical/minimum waist, iliac/trochanter hip, thigh). Several waist-to-hip/waist-to-thigh ratios (WHR/WTR) were constructed. A CT-scan with calculation of cross-sectional abdominal fat areas was obtained in 37 cases.

RESULTS: Severe acute pancreatitis occurred in 25 patients. Waist circumference (WC), WHR and WTR - all using the umbilical reference - most accurately predicted severe acute pancreatitis. Only umbilical WC was retained in multivariate analysis: the risk for severe acute pancreatitis increased 16% with every 1 cm (OR 1.16, 95%CI: 1.1-1.3). Abdominal obesity caused a 6-fold increase in risk. Umbilical WC correlated best with subcutaneous fat area (r = 0.791, P < 0.001), whereas WHR with intra-abdominal (r = 0.594, P < 0.001).

CONCLUSIONS: Abdominal obesity according to umbilical WC is a better predictor for development of severe acute pancreatitis than BMI, minimum WC, WHR and WTR. The protocol for anthropometry must be standardized as it may affect results. Both subcutaneous and intra-abdominal fat appears to affect the likelihood of a severe outcome.

Author List

Duarte-Rojo A, Sosa-Lozano LA, Saúl A, Herrera-Cáceres JO, Hernández-Cárdenas C, Vázquez-Lamadrid J, Robles-Díaz G

Author

Luis Antonio Sosa Lozano MD Chief, Associate Professor in the Radiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Abdominal Fat
Adult
Anthropometry
Body Mass Index
Female
Humans
Male
Middle Aged
Obesity, Abdominal
Pancreatitis
Prognosis
Severity of Illness Index
Tomography, X-Ray Computed
Waist Circumference