Frozen sections in patients undergoing breast conserving surgery at a single ambulatory surgical center: 5 year experience. Eur J Surg Oncol 2017 Jul;43(7):1273-1281
Date
02/22/2017Pubmed ID
28215733DOI
10.1016/j.ejso.2017.01.237Scopus ID
2-s2.0-85013040606 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
OBJECTIVES: To evaluate outcomes of our breast frozen section (FS) practice in its first 5 years, including our specialized FS of margins (FSM) procedure for breast conserving therapy (BCT) patients.
METHODS: One thousand two hundred and forty eight patients undergoing 1303 breast FSM and/or sentinel lymph node (SLN) FS were included. Clinicopathologic features were assessed by chart review.
RESULTS: Use of SLN FS declined, from 43.5% of FS cases before to 19.2% of FS cases after 2012. FSM patients had a decline in overall reexcision to 12.3% in 2013-2014 (p = 0.063). There was also decline in reexcision for focally close margins (p < 0.0001) but no change in reexcision for extensively close margins. Reexcision was significantly associated with lobular subtype, multifocality and larger (≥T2) size. False negative FSM cases were most often influenced by extensively close or positive final (reexcised) margins sent for permanent section only (96/148; 64.9%).
CONCLUSIONS: Despite changing surgical practices, FSM remains a valuable service that reduces reexcision in BCT patients.
Author List
Jorns JM, Daignault S, Sabel MS, Myers JL, Wu AJAuthor
Julie M. Jorns MD Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Aged, 80 and over
Breast Neoplasms
Breast Neoplasms, Male
Carcinoma, Ductal, Breast
Carcinoma, Intraductal, Noninfiltrating
Carcinoma, Lobular
Female
Frozen Sections
Humans
Intraoperative Period
Male
Margins of Excision
Mastectomy, Segmental
Middle Aged
Reoperation
Sentinel Lymph Node
Sentinel Lymph Node Biopsy
Surgicenters
Tumor Burden
Young Adult
