Comparative effectiveness of faecal microbiota transplant by route of administration. J Hosp Infect 2017 Aug;96(4):349-352
Date
05/16/2017Pubmed ID
28501333DOI
10.1016/j.jhin.2017.05.004Scopus ID
2-s2.0-85021105830 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
The optimal route of delivery for faecal microbiota transplant (FMT) is unknown. This observational single-centre study analysed the two-week cure rates for all patients who received FMT from 2013 to 2016 according to route of delivery. Overall, nasogastric delivery of FMT was less effective than lower endoscopic delivery. When patients were stratified by illness severity, nasogastric delivery achieved similar cure rates in healthier individuals, whereas lower endoscopic delivery was preferred for relatively ill individuals. Nasogastric delivery may be less effective than lower endoscopic delivery; however, when taking the cost, preparation and potential risk into account, this difference may not be clinically significant for patients with mild disease.
Author List
Gundacker ND, Tamhane A, Walker JB, Morrow CD, Rodriguez JMAuthor
Nathan D. Gundacker MD Assistant Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Aged, 80 and over
Fecal Microbiota Transplantation
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prospective Studies
Treatment Outcome
