Faculty Collaboration Database

Congenital capillary proliferation of the kidney: a distinctive renal vascular lesion of childhood. Hum Pathol 2017 Aug;66:59-66

Date

05/31/2017

Pubmed ID

28554576

DOI

10.1016/j.humpath.2017.05.018

Scopus ID

2-s2.0-85026751817 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

Renal vascular lesions (RVL) are rare, and their morphological spectrum remains largely unknown, particularly in children. In this study, we characterize the clinicopathological features of RVL in a cohort of 12 children. Seven lesions were classified as previously recognized entities: vascular malformations (4), papillary endothelial hyperplasia (2), and pyogenic granuloma (lobular capillary hemangioma; 1). An eighth lesion showed nonspecific findings, which were interpreted as reactive during our review. The remaining 4 cases presented either prenatally, at birth, or shortly after birth and were morphologically similar. These were characterized by a peculiar pattern of capillary proliferation with entrapment of native renal structures, variable amounts of extramedullary hematopoiesis and reactive lymphocytes, foci of infarction and hemorrhage, and the presence of feeding and draining vessels at their periphery. To our knowledge, this represents a previously undescribed congenital vascular lesion involving the kidney, which we have descriptively and provisionally termed congenital capillary proliferation of the kidney (CCPK). While it is unclear whether CCPK represents a malformation or neoplastic proliferation, it shows overlapping features with congenital hemangioma of the liver (solitary congenital hepatic hemangioma) and congenital nonprogressive hemangioma (CNH) of the skin and soft tissue, suggesting a possible common pathogenesis among these 3 entities.

Author List

Cajaiba MM, North PE, Gong S, Dickman PS, Mroczek-Musulman E, Sauer DA, Perlman EJ

Author

Paula E. North MD, PhD Professor in the Pathology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Age Factors
Antigens, CD34
Biomarkers
Biopsy
Capillaries
Child
Child, Preschool
Female
Hemangioma, Capillary
Humans
Immunohistochemistry
Infant
Infant, Newborn
Kidney
Kidney Neoplasms
Male
Neovascularization, Pathologic
Nephrectomy
Vascular Malformations