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Factors Determining the Oxygen Permeability of Biological Membranes: Oxygen Transport Across Eye Lens Fiber-Cell Plasma Membranes. Adv Exp Med Biol 2017;977:27-34

Date

07/08/2017

Pubmed ID

28685424

Pubmed Central ID

PMC5851008

DOI

10.1007/978-3-319-55231-6_5

Abstract

Electron paramagnetic resonance (EPR) spin-label oximetry allows the oxygen permeability coefficient to be evaluated across homogeneous lipid bilayer membranes and, in some cases, across coexisting membrane domains without their physical separation. The most pronounced effect on oxygen permeability is observed for cholesterol, which additionally induces the formation of membrane domains. In intact biological membranes, integral proteins induce the formation of boundary and trapped lipid domains with a low oxygen permeability. The effective oxygen permeability coefficient across the intact biological membrane is affected not only by the oxygen permeability coefficients evaluated for each lipid domain but also by the surface area occupied by these domains in the membrane. All these factors observed in fiber cell plasma membranes of clear human eye lenses are reviewed here.

Author List

Subczynski WK, Widomska J, Mainali L

Author

Witold K. Subczynski PhD Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Biological Transport
Cell Membrane
Cell Membrane Permeability
Electron Spin Resonance Spectroscopy
Humans
Lens, Crystalline
Lipid Bilayers
Membrane Lipids
Optic Nerve
Oxygen
Permeability