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Non-cannabinoid constituents from a high potency Cannabis sativa variety. Phytochemistry 2008 Oct;69(14):2627-33

Date

09/09/2008

Pubmed ID

18774146

Pubmed Central ID

PMC4888767

DOI

10.1016/j.phytochem.2008.07.010

Scopus ID

2-s2.0-56949101880 (requires institutional sign-in at Scopus site)   108 Citations

Abstract

Six new non-cannabinoid constituents were isolated from a high potency Cannabis sativa L. variety, namely 5-acetoxy-6-geranyl-3-n-pentyl-1,4-benzoquinone (1), 4,5-dihydroxy-2,3,6-trimethoxy-9,10-dihydrophenanthrene (2), 4-hydroxy-2,3,6,7-tetramethoxy-9,10-dihydrophenanthrene (3), 4,7-dimethoxy-1,2,5-trihydroxyphenanthrene (4), cannflavin C (5) and beta-sitosteryl-3-O-beta-d-glucopyranoside-2'-O-palmitate (6). In addition, five known compounds, alpha-cannabispiranol (7), chrysoeriol (8), 6-prenylapigenin (9), cannflavin A (10) and beta-acetyl cannabispiranol (11) were identified, with 8 and 9 being reported for the first time from cannabis. Some isolates displayed weak to strong antimicrobial, antileishmanial, antimalarial and anti-oxidant activities. Compounds 2-4 were inactive as analgesics.

Author List

Radwan MM, Elsohly MA, Slade D, Ahmed SA, Wilson L, El-Alfy AT, Khan IA, Ross SA

Author

Abir El-Alfy PhD Assistant Dean, Professor in the School of Pharmacy Administration department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Analgesics
Animals
Anti-Infective Agents
Antimalarials
Antioxidants
Antiprotozoal Agents
Biological Products
Cannabis
Flavones
Mice
Molecular Structure