Risk of ventricular dysrhythmias during 1-hour infusions of amphotericin B in patients with preserved renal function. Antimicrob Agents Chemother 1992 Nov;36(11):2542-3
Date
11/01/1992Pubmed ID
1489202Pubmed Central ID
PMC284371DOI
10.1128/AAC.36.11.2542Scopus ID
2-s2.0-0026446193 (requires institutional sign-in at Scopus site) 18 CitationsAbstract
In order to assess the safety of 1-h infusions of amphotericin B (AMB), we prospectively monitored 213 1-h infusions of AMB (dose range, 0.27 to 0.89 mg/kg of body weight) in 27 patients with creatinine clearances of > 25 ml/min. Holter monitor tracings during 1-h infusions were compared with those during a 4-h baseline period of monitoring. There were no ventricular dysrhythmias during 1-h infusions of AMB that were not present during baseline monitoring. Nausea and/or rigors were noted for 32 (15%) infusions in six (22%) patients. No patient exhibited a temperature rise of > 1 degree C. We conclude that, in doses of up to 0.9 mg/kg, AMB does not appear to induce asymptomatic ventricular dysrhythmias when administered over 1 h to patients with creatinine clearances of > 25 ml/min.
Author List
Bowler WA, Weiss PJ, Hill HE, Hoffmeister KA, Fleck RP, Blacky AR, Oldfield EC 3rdAuthor
Karin Hoffmeister MD Professor in the Biochemistry department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Amphotericin B
Arrhythmias, Cardiac
Drug Administration Schedule
Electrocardiography, Ambulatory
Female
Heart Ventricles
Humans
Infusions, Intravenous
Kidney
Male
Middle Aged
Prospective Studies
Ventricular Fibrillation
Ventricular Function
