Faculty Collaboration Database

Dehydrogenation of reduced pyridine nucleotides by Leydig cell tumors of the rat testis. Proc Soc Exp Biol Med 1976 Feb;151(2):418-21

Date

02/01/1976

Pubmed ID

2936

DOI

10.3181/00379727-151-39224

Scopus ID

2-s2.0-0017229201 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

The activities of the cytochrome c reductases and of the D-T diaphorase in rat Leydig cell tumors have been described. The increase in enzymatic activity of the NADH cytochrome c reductase activity in functional tumors derived from interstitial cells of the rat testis is interpreted as being possibly related to hydroxylation of steroids by the neoplastic cells. Meanwhile, the increase in the activity of the D-T diaphorase in the other tumor is interpreted as being an anaplerotic reaction to substitute for the deficient shuttles for the transfer of reducing equivalents from the cytoplasm to the mitochondria observed in tumors.

Author List

Schor NA, Rice BF, Huseby RA, Dunlap CE

Author

Paul Joseph Pearson MD, PhD Chief, Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Cell Fractionation
Cytochrome Reductases
Cytosol
Leydig Cell Tumor
Male
Microsomes
Mitochondria
NADP
Neoplasms, Experimental
Quinone Reductases
Rats