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The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels. Cell Calcium 2011 Aug;50(2):157-67

Date

05/03/2011

Pubmed ID

21529939

Pubmed Central ID

PMC3160778

DOI

10.1016/j.ceca.2011.03.011

Abstract

Accumulating evidence suggests that the endo-lysosomal system provides a substantial store of Ca(2+) that is tapped by the Ca(2+)-mobilizing messenger, NAADP. In this article, we review evidence that NAADP-mediated Ca(2+) release from this acidic Ca(2+) store proceeds through activation of the newly described two-pore channels (TPCs). We discuss recent advances in defining the sub-cellular targeting, topology and biophysics of TPCs. We also discuss physiological roles and the evolution of this ubiquitous ion channel family.

Author List

Patel S, Ramakrishnan L, Rahman T, Hamdoun A, Marchant JS, Taylor CW, Brailoiu E

Author

Jonathan S. Marchant PhD Chair, Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Acids
Animals
Calcium
Calcium Channels
Cell Membrane
Endosomes
Humans
Ion Channel Gating
Lysosomes
NADP
Potassium Channels, Voltage-Gated
Sodium Channels
Sodium-Calcium Exchanger
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a