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Localization and socialization: experimental insights into the functional architecture of IP3 receptors. Chaos 2009 Sep;19(3):037103

Date

10/02/2009

Pubmed ID

19792028

Pubmed Central ID

PMC2771704

DOI

10.1063/1.3147425

Scopus ID

2-s2.0-70349634912   13 Citations

Abstract

Inositol 1,4,5-trisphosphate (IP(3))-evoked Ca(2+) signals display great spatiotemporal malleability. This malleability depends on diversity in both the cellular organization and in situ functionality of IP(3) receptors (IP(3)Rs) that regulate Ca(2+) release from the endoplasmic reticulum (ER). Recent experimental data imply that these considerations are not independent, such that-as with other ion channels-the local organization of IP(3)Rs impacts their functionality, and reciprocally IP(3)R activity impacts their organization within native ER membranes. Here, we (i) review experimental data that lead to our understanding of the "functional architecture" of IP(3)Rs within the ER, (ii) propose an updated terminology to span the organizational hierarchy of IP(3)Rs observed in intact cells, and (iii) speculate on the physiological significance of IP(3)R socialization in Ca(2+) dynamics, and consequently the emerging need for modeling studies to move beyond gridded, planar, and static simulations of IP(3)R clustering even over short experimental timescales.

Author List

Diambra L, Marchant JS

Author

Jonathan S. Marchant PhD Chair, Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Algorithms
Animals
Biological Clocks
Calcium Signaling
Computer Simulation
Humans
Inositol 1,4,5-Trisphosphate Receptors
Ion Channel Gating
Models, Biological
Nonlinear Dynamics
Oscillometry
Subcellular Fractions
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a