Faculty Collaboration Database

Risk of morbidity following catheter removal among neonates with catheter associated bloodstream infection. J Neonatal Perinatal Med 2017;10(3):291-299

Date

09/01/2017

Pubmed ID

28854516

DOI

10.3233/NPM-16137

Scopus ID

2-s2.0-85031771506 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

OBJECTIVE: We hypothesized that infectious morbidities following percutaneously inserted central venous catheter (PICC) removal would be greater among neonates with central-line associated bloodstream infection (CLBASI).

STUDY DESIGN: This retrospective cohort study, included all neonates who required a PICC over a ten-year period. Outcomes assessed following PICC removal included: late bloodstream infection, rule-out sepsis workups, need for a subsequent PICC and antibiotic days and PICC days after PICC removal. Odds ratios (OR) and 95% confidence intervals (CI) were determined for outcomes. Regression analyses were used to control for confounders.

RESULTS: Two-thousand nine hundred and thirteen neonates required at least one PICC during the study period. After adjusting for confounders neonates with CLABSI were 3.4 (95% confidence interval (CI) 2.5, 4.6) and 2.2 (95% CI 1.2, 4.0) times more likely respectively to require a subsequent PICC or develop a late bloodstream infection after PICC removal. Neonates with CLABSI required 1.33 (95% CI 0.77, 1.89) more days of antibiotic treatment and 6.85 (95% CI 5.34, 8.37) more PICC days following PICC removal than neonates without a CLABSI.

CONCLUSIONS: Neonates with CLABSI are at risk for additional infectious morbidities after PICC removal. Future intervention studies aimed at reducing CLABSI should evaluate whether morbidities following catheterization are also reduced.

Author List

Garland JS, Kanneberg S, Mayr KA, Porter DM, Vanden Heuvel A, Kurziak J, McAuliffe TL

Author

Timothy L. McAuliffe PhD Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Anti-Bacterial Agents
Bacteremia
Catheter-Related Infections
Catheterization, Peripheral
Central Venous Catheters
Cohort Studies
Device Removal
Female
Humans
Infant, Extremely Low Birth Weight
Infant, Extremely Premature
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight
Linear Models
Logistic Models
Male
Neonatal Sepsis
Odds Ratio
Retrospective Studies
Time Factors