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Urinary N-acetyl-beta-glucosaminidase in normal Chinese children and children with pyelonephritis. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 1991 Jan-Feb;32(1):24-30

Date

01/01/1991

Pubmed ID

2063674

Abstract

Urinary excretion of N-acetyl-beta-glucosaminidase (NAG) was measured in random urine as the ratio of NAG to grams of urinary creatinine in 120 normal Chinese children. The results showed that the NAG was elevated in newborn babies and infants, and decreased to adult level after two years of age. Thirteen children with urinary tract infection, who were clinically suggested or proved to have pyelonephritis, were evaluated for their urinary NAG excretion. The level of enzymuria at diagnosis in these patients was significantly higher than that of normal children for age. Eleven longitudinal follow-up data including levels at diagnosis, end of treatment, and two to four weeks after treatment showed that the mean urinary NAG at diagnosis was 109.82 +/- 87.30 u/g creatinine, compared with 75.26 +/- 48.82 u/g creatinine at the end of treatment and 15.37 +/- 9.69 u/g creatinine after recovery. These data suggest the presence of renal tubular cell injury in upper urinary tract infection. Thus urinary NAG may play a role in differentiating lower from upper urinary tract infections.

Author List

Tsau YK, Chen CH, Teng RJ, Tsai WS, Sheu JN

Author

Ru-Jeng Teng MD Associate Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Acetylglucosaminidase
Adolescent
Adult
Child
Child, Preschool
Creatinine
Female
Humans
Infant
Infant, Newborn
Male
Pyelonephritis
Reference Values
Urinary Tract Infections
jenkins-FCD Prod-478 d1509cf07a111124a2d122fd3df854cc0b993c00