Faculty Collaboration Database

Protective effect of Thuja occidentalis against radiation-induced toxicity in mice. Integr Cancer Ther 2005 Dec;4(4):322-8

Date

11/12/2005

Pubmed ID

16282509

DOI

10.1177/1534735405282251

Scopus ID

2-s2.0-28144443382 (requires institutional sign-in at Scopus site)   16 Citations

Abstract

The effect of Thuja occidentalis against damage induced by gamma radiation was studied. Whole-body exposure of Swiss albino mice to gamma-rays (6 Gy) reduced the total white blood cell count to 1900 cells/mm(3) on the third day, which was elevated to 2050 cells/mm(3) by the administration of alcoholic extract ofT occidentalis (5 mg/dose/animal, intraperitoneally). Six animals from each group were killed after 2, 7, and 11 days of irradiation to detect the bone marrow cellularity and radiation-induced toxicity. The number of bone marrow cells and alpha-esterase positive cells in control animals after 11 days was reduced to 12.2 x 10(6) cells/femur and 693.5/4000 cells, respectively. In T occidentalis-treated animals, bone marrow cellularity was increased to 16.9 x 10(6) cells/femur and alpha-esterase positive cells were 940/4000 cells, a nearly normal level. Alcoholic extract of T occidentalis reduced the elevated levels of GPT and alkaline phosphatase in liver and serum after irradiation. The lipid peroxidation levels were also lowered in the irradiated animals treated with the Thuja extract.

Author List

Sunila ES, Kuttan G

Author

Sunila Pradeep PhD Associate Professor in the Obstetrics and Gynecology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Disease Models, Animal
Gamma Rays
Intestinal Diseases
Intestine, Small
Male
Mice
Phytotherapy
Plant Extracts
Radiation Injuries, Experimental
Thuja