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Successful Treatment of Invasive Conidiobolus Infection During Therapy for Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol 2018 10;40(7):e446-e449

Date

10/11/2017

Pubmed ID

28991126

Pubmed Central ID

PMC5904005

DOI

10.1097/MPH.0000000000000985

Scopus ID

2-s2.0-85031495362   5 Citations

Abstract

Invasive fungal infections are a serious cause of morbidity and mortality in patients with hematologic malignancies. Conidiobolus species are molds within the order Entomophthorales and may disseminate to become rapidly fatal in immunocompromised individuals. This species of fungal infections are often multidrug resistant (MDR) and present unique therapeutic challenges. Reports of Conidiobolus infections are rare in pediatric oncology. We report the successful treatment of an adolescent male with B-cell lymphoblastic leukemia and MDR invasive sinopulmonary Conidiobolus infection with emphasis on early and aggressive neutrophil support with surgical debridement. The strategies described could be applied to other MDR fungal infections.

Author List

Erker C, Huppler AR, Walsh TJ, McCormick ME, Suchi M, Bhatt NS, Kehl SC, Southwood J, Harker-Murray P

Authors

Paul D. Harker-Murray MD, PhD Associate Professor in the Pediatrics department at Medical College of Wisconsin
Anna H. Huppler MD Assistant Professor in the Pediatrics department at Medical College of Wisconsin
Karen Sue Kehl PhD Professor in the Pathology department at Medical College of Wisconsin
Michael E. McCormick MD Associate Professor in the Otolaryngology department at Medical College of Wisconsin
Mariko Suchi MD, PhD Associate Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Antifungal Agents
Conidiobolus
Drug Resistance, Multiple
Granulocyte-Macrophage Colony-Stimulating Factor
Granulocytes
Humans
Male
Mycoses
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Remission Induction
Zygomycosis
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a