Independent activation of hepatitis B virus biosynthesis by retinoids, peroxisome proliferators, and bile acids. J Virol 2013 Jan;87(2):991-7
Date
11/09/2012Pubmed ID
23135717Pubmed Central ID
PMC3554059DOI
10.1128/JVI.01562-12Scopus ID
2-s2.0-84871944865 (requires institutional sign-in at Scopus site) 35 CitationsAbstract
In the human hepatoma cell line HepG2, retinoic acid, clofibric acid, and bile acid treatment can only modestly increase hepatitis B virus (HBV) biosynthesis. Utilizing the human embryonic kidney cell line 293T, it was possible to demonstrate that the retinoid X receptor α (RXRα) plus its ligand can support viral biosynthesis independently of additional nuclear receptors. In addition, RXRα/peroxisome proliferator-activated receptor α (PPARα) and RXRα/farnesoid X receptor α (FXRα) heterodimeric nuclear receptors can also mediate ligand-dependent HBV transcription and replication when activated by clofibric acid and bile acid, respectively, independently of a requirement for the ligand-dependent activation of RXRα. These observations indicate that there are at least three possible modes of ligand-mediated activation of HBV transcription and replication existing within hepatocytes, suggesting that multiple independent mechanisms control viral production in the livers of infected individuals.
Author List
Reese VC, Oropeza CE, McLachlan AAuthor
Vanessa Mcfadden MD Associate Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Bile Acids and SaltsCell Line
Epithelial Cells
Hepatitis B virus
Hepatocytes
Humans
Peroxisome Proliferators
Retinoids
Transcription, Genetic
Transcriptional Activation
Virus Replication
