Faculty Collaboration Database

Haemodynamic profiles of children with end-stage heart failure. Eur Heart J 2017 Oct 07;38(38):2900-2909

Date

10/12/2017

Pubmed ID

29019615

DOI

10.1093/eurheartj/ehx456

Scopus ID

2-s2.0-85032730948 (requires institutional sign-in at Scopus site)   23 Citations

Abstract

AIMS: To evaluate associations between haemodynamic profiles and symptoms, end-organ function and outcome in children listed for heart transplantation.

METHODS AND RESULTS: Children <18 years listed for heart transplant between 1993 and 2013 with cardiac catheterization data [pulmonary capillary wedge pressure (PCWP), right atrial pressure (RAP), and cardiac index (CI)] in the Pediatric Heart Transplant Study database were included. Outcomes were New York Heart Association (NYHA)/Ross classification, renal and hepatic dysfunction, and death or clinical deterioration while on waitlist. Among 1059 children analysed, median age was 6.9 years and 46% had dilated cardiomyopathy. Overall, 58% had congestion (PCWP >15 mmHg), 28% had severe congestion (PCWP >22 mmHg), and 22% low cardiac output (CI < 2.2 L/min/m2). Twenty-one per cent met the primary outcome of death (9%) or clinical deterioration (12%). In multivariable analysis, worse NYHA/Ross classification was associated with increased PCWP [odds ratio (OR) 1.03, 95% confidence interval (95% CI) 1.01-1.07, P = 0.01], renal dysfunction with increased RAP (OR 1.04, 95% CI 1.01-1.08, P = 0.007), and hepatic dysfunction with both increased PCWP (OR 1.03, 95% CI 1.01-1.06, P < 0.001) and increased RAP (OR 1.09, 95% CI 1.06-1.12, P < 0.001). There were no associations with low output. Death or clinical deterioration was associated with severe congestion (OR 1.6, 95% CI 1.2-2.2, P = 0.002), but not with CI alone. However, children with both low output and severe congestion were at highest risk (OR 1.9, 95% CI 1.1-3.5, P = 0.03).

CONCLUSION: Congestion is more common than low cardiac output in children with end-stage heart failure and correlates with NYHA/Ross classification and end-organ dysfunction. Children with both congestion and low output have the highest risk of death or clinical deterioration.

Author List

Chen S, Dykes JC, McElhinney DB, Gajarski RJ, Shin AY, Hollander SA, Everitt ME, Price JF, Thiagarajan RR, Kindel SJ, Rossano JW, Kaufman BD, May LJ, Pruitt E, Rosenthal DN, Almond CS

Author

Steven J. Kindel MD Associate Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Cardiac Output, Low
Cardiomyopathies
Child
Child, Preschool
Chronic Disease
Clinical Deterioration
Female
Heart Failure
Heart Ventricles
Hemodynamics
Humans
Infant
Infant, Newborn
Male