Association and linkage studies of immunoglobulin heavy chain allotypes in inflammatory bowel disease. Tissue Antigens 1988 May;31(5):243-9
Date
05/01/1988Pubmed ID
3135639DOI
10.1111/j.1399-0039.1988.tb02090.xScopus ID
2-s2.0-0023902448 (requires institutional sign-in at Scopus site) 6 CitationsAbstract
Inflammatory bowel disease is a familial disorder of unknown etiology, characterized by a variety of immunological abnormalities for which there are no proven genetic markers. Studies of immunoglobulin heavy chain and light chain allotypes were undertaken in 89 patients with Crohn's disease and in 18 families with ulcerative colitis or Crohn's disease in at least two first-degree relatives, to search for association and/or linkage between a postulated disease susceptibility locus and an immunoglobulin allotype locus. No evidence of association or linkage with a specific immunoglobulin allotype was found.
Author List
Gudjonsson H, Schanfield MS, Albertini RJ, McAuliffe TL, Beeken WL, Krawitt ELAuthor
Timothy L. McAuliffe PhD Professor in the Psychiatry and Behavioral Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Child
Child, Preschool
Colitis, Ulcerative
Crohn Disease
Female
Genetic Linkage
Humans
Immunoglobulin Allotypes
Immunoglobulin Heavy Chains
Male
Middle Aged
