Faculty Collaboration Database

Carotid body dopaminergic mechanisms are functional after acclimatization to hypoxia in goats. Respir Physiol 1998 Jan;111(1):25-32

Date

03/13/1998

Pubmed ID

9496469

DOI

10.1016/s0034-5687(97)00060-1

Scopus ID

2-s2.0-0031963774 (requires institutional sign-in at Scopus site)   22 Citations

Abstract

Ventilatory acclimatization to sustained hypoxia (VASH) is the time-dependent increase in ventilation that occurs during prolonged exposure to hypoxia. We tested the hypothesis that carotid body (CB) dopaminergic mechanisms are down-regulated during VASH, which would allow CB afferent discharge and ventilation to increase beyond the initial response to hypoxia. Domperidone (DOM; 1.0 mg.kg-1) was administered intravenously to block CB dopamine (DA) receptors after VASH was complete in awake goats. DOM caused a significant augmentation of the ventilatory response to hypoxia in acclimatized goats, failing to support the hypothesis. We conclude that inhibitory CB dopaminergic function is not significantly reduced following prolonged hypoxia, and that down-regulation of CB dopaminergic mechanisms may not be involved in VASH in the goat.

Author List

Janssen PL, O'Halloran KD, Pizarro J, Dwinell MR, Bisgard GE

Author

Melinda R. Dwinell PhD Professor in the Physiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Acclimatization
Animals
Carotid Body
Chemoreceptor Cells
Domperidone
Female
Goats
Hypoxia
Male
Pulmonary Ventilation
Receptors, Dopamine D2