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Bioavailability of a film-coated tablet of valproate in nonfasting volunteers. Jpn J Psychiatry Neurol 1987 Dec;41(4):693-8

Date

12/01/1987

Pubmed ID

3134567

DOI

10.1111/j.1440-1819.1987.tb00427.x

Scopus ID

2-s2.0-0023623768   5 Citations

Abstract

The bioavailability of a film-coated tablet of valproate (VPA) in nonfasting volunteers was studied. Ten healthy adults received a single 200 mg (mean 3.55 mg/kg) film-coated tablet, 15 minutes after breakfast. Venous blood was then taken at regular intervals of up to 4 or 7 hours after the dosage, and the serum VPA concentrations were determined by means of a fluorescence polarization immunoassay. VPA was slowly absorbed with the peak concentrations occurring 1.5 to 4 hours after the administration. The mean concentration (Cmax) and extent of absorption (area under the concentration-time curve) between 1 and 4 hours were 22.2 micrograms/ml and 59.3 micrograms.h/ml, respectively. It was concluded that Cmax with a film-coated tablet of VPA can be detected if blood is taken at around 3 hours after the dosage under nonfasting conditions.

Author List

Ishikawa T, Horie M, Furuyama M, Ohuchi M, Awaya A, Sobajima H, Suchi M, Yamaguchi A, Okajima K, Wanibe M

Author

Mariko Suchi MD, PhD Associate Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Biological Availability
Female
Humans
Intestinal Absorption
Male
Tablets, Enteric-Coated
Valproic Acid
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a