Bioavailability of a film-coated tablet of valproate in nonfasting volunteers. Jpn J Psychiatry Neurol 1987 Dec;41(4):693-8
Date
12/01/1987Pubmed ID
3134567DOI
10.1111/j.1440-1819.1987.tb00427.xScopus ID
2-s2.0-0023623768 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
The bioavailability of a film-coated tablet of valproate (VPA) in nonfasting volunteers was studied. Ten healthy adults received a single 200 mg (mean 3.55 mg/kg) film-coated tablet, 15 minutes after breakfast. Venous blood was then taken at regular intervals of up to 4 or 7 hours after the dosage, and the serum VPA concentrations were determined by means of a fluorescence polarization immunoassay. VPA was slowly absorbed with the peak concentrations occurring 1.5 to 4 hours after the administration. The mean concentration (Cmax) and extent of absorption (area under the concentration-time curve) between 1 and 4 hours were 22.2 micrograms/ml and 59.3 micrograms.h/ml, respectively. It was concluded that Cmax with a film-coated tablet of VPA can be detected if blood is taken at around 3 hours after the dosage under nonfasting conditions.
Author List
Ishikawa T, Horie M, Furuyama M, Ohuchi M, Awaya A, Sobajima H, Suchi M, Yamaguchi A, Okajima K, Wanibe MAuthor
Mariko Suchi MD, PhD Associate Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultBiological Availability
Female
Humans
Intestinal Absorption
Male
Tablets, Enteric-Coated
Valproic Acid
