Cell-based therapeutic strategies for multiple sclerosis. Brain 2017 Nov 01;140(11):2776-2796
Date
10/21/2017Pubmed ID
29053779Pubmed Central ID
PMC5841198DOI
10.1093/brain/awx154Scopus ID
2-s2.0-85032909723 (requires institutional sign-in at Scopus site) 142 CitationsAbstract
The availability of multiple disease-modifying medications with regulatory approval to treat multiple sclerosis illustrates the substantial progress made in therapy of the disease. However, all are only partially effective in preventing inflammatory tissue damage in the central nervous system and none directly promotes repair. Cell-based therapies, including immunoablation followed by autologous haematopoietic stem cell transplantation, mesenchymal and related stem cell transplantation, pharmacologic manipulation of endogenous stem cells to enhance their reparative capabilities, and transplantation of oligodendrocyte progenitor cells, have generated substantial interest as novel therapeutic strategies for immune modulation, neuroprotection, or repair of the damaged central nervous system in multiple sclerosis. Each approach has potential advantages but also safety concerns and unresolved questions. Moreover, clinical trials of cell-based therapies present several unique methodological and ethical issues. We summarize here the status of cell-based therapies to treat multiple sclerosis and make consensus recommendations for future research and clinical trials.
Author List
Scolding NJ, Pasquini M, Reingold SC, Cohen JA, International Conference on Cell-Based Therapies for Multiple Sclerosis, International Conference on Cell-Based Therapies for Multiple Sclerosis, International Conference on Cell-Based Therapies for Multiple SclerosisAuthor
Marcelo C. Pasquini MD, MS Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Hematopoietic Stem Cell TransplantationHumans
Induced Pluripotent Stem Cells
Mesenchymal Stem Cell Transplantation
Multiple Sclerosis
Myelin Sheath
Oligodendroglia
Regeneration
Stem Cell Transplantation
Stem Cells
Transplantation, Autologous
