The reintroduction of DENV-2 in 2011 in Panama and subsequent outbreak characteristic. Acta Trop 2018 Jan;177:58-65
Date
10/08/2017Pubmed ID
28986247Pubmed Central ID
PMC6295316DOI
10.1016/j.actatropica.2017.09.031Scopus ID
2-s2.0-85030714802 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
The circulation of the South-east Asian/American (AS/AM) dengue 2 virus (DENV-2) genotype in the Americas has been associated with a high rate of severe disease. From 1993, the year DENV was reintroduced in Panama, until 2011 there were 29 dengue-associated deaths, 17 of which occurred in 2011, the most severe outbreak with a case fatality rate (CFR) of 44% (17 deaths out of 38 severe dengue cases). During this outbreak DENV-2 was reintroduced into the country, whereas over the prior five years DENV-1 and -3 were predominant. Herein, we describe the 2011 Panama outbreak and genetically characterize the Panamanian DENV-2 strains, which were associated with severe dengue disease in Panama. Our results suggest that the DENV-2 isolates from this outbreak belonged to the AS/AM genotype sub-clade 2BI and were genetically close to viruses described in the outbreaks in Nicaragua, Honduras, Guatemala and Mexico from 2006-2011. Sub-clade 2BI has previously been associated with severe disease in Nicaragua during outbreaks from 2005-2007.
Author List
Díaz Y, Cisneros J, Guzmán H, Cordoba P, Carrera JP, Moreno B, Chen R, Mewa JC, García L, Cerezo L, da Rosa AT, Gundacker ND, Armién B, Weaver SC, Vasilakis N, López-Vergès S, Tesh RAuthor
Nathan D. Gundacker MD Assistant Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Child
Child, Preschool
Dengue
Dengue Virus
Disease Outbreaks
Female
Genotype
Humans
Infant
Male
Middle Aged
Panama
Phylogeny
Severe Dengue
Young Adult
